This innovation provides a novel method for growing functional, transplantable organs using donated human placentas as a biological perfusion system. The process involves connecting the placenta-either natural or decellularized-to a patient's vascular system via surgical tubing, allowing the patient's blood to perfuse the placenta. The placenta, housed in an external chamber alongside an organ scaffold seeded with patient-derived stem cells, supports the growth of a vascularized, functional organ over time. The pla-centa's natural angiogenic properties, combined with its ability to deliver nutrients and modulate immune responses, create an optimal environment for organ development that bioreactor systems struggle to replicate. By using freely available placentas-which are typically discarded after childbirth-this method offers a sustainable, ethical, and scalable approach to address the global organ shortage. For patients facing certain death without a transplant, this technique provides a critical last-resort option, particularly when traditional transplant routes are not viable. Additionally, decellularized placentas can be used to further reduce immune risks, offering flexibility in cases where tissue compatibility is a concern. While the primary strategy centers on human placentas, the method also includes alternative embodiments involving animal models as perfusion systems for organ growth or drug testing, though these are secondary approaches intended for specific scenarios. By leveraging the placenta's unique biological properties, this invention has the potential to revolutionize organ fabrication, offering improved organ viability, reduced rejection risks, and personalized transplant solutions, while contributing to the ethical use of biological resources. (I am looking for internet or feedback on this project).
This innovation provides a novel method for growing functional, transplantable organs using donated human placentas as a biological perfusion system. The process involves connecting the placenta-either natural or decellularized-to a patient's vascular system via surgical tubing, allowing the patient's blood to perfuse the placenta. The placenta, housed in an external chamber alongside an organ scaffold seeded with patient-derived stem cells, supports the growth of a vascularized, functional organ over time. The pla-centa's natural angiogenic properties, combined with its ability to deliver nutrients and modulate immune responses, create an optimal environment for organ development that bioreactor systems struggle to replicate. By using freely available placentas-which are typically discarded after childbirth-this method offers a sustainable, ethical, and scalable approach to address the global organ shortage. For patients facing certain death without a transplant, this technique provides a critical last-resort option, particularly when traditional transplant routes are not viable. Additionally, decellularized placentas can be used to further reduce immune risks, offering flexibility in cases where tissue compatibility is a concern. While the primary strategy centers on human placentas, the method also includes alternative embodiments involving animal models as perfusion systems for organ growth or drug testing, though these are secondary approaches intended for specific scenarios. By leveraging the placenta's unique biological properties, this invention has the potential to revolutionize organ fabrication, offering improved organ viability, reduced rejection risks, and personalized transplant solutions, while contributing to the ethical use of biological resources. (I am looking for internet or feedback on this project).